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ПОБОЧНЫЕ ЭФФЕКТЫ: Частые побочные эффекты включают головную боль, ажитацию, головокружение, сонливость, увеличение веса и расстройство желудка. Кветиапин может вызывать ортостатическую гипотензию (снижение артериального давления при стоянии, которое может привести к головокружению или обморокам), особенно в течение первого 3-5-дневного периода лечения, когда он возобновляется после временного прекращения приема и после увеличения дозы. Риск ортостатической гипотензии составляет около 1 из 100 (одна из каждых сотен пациентов, принимающих кветиапин). Кветиапин часто вызывает усталость (1 из 5 пациентов), особенно в течение первых 3-5 дней лечения. Из-за этой усталости следует проявлять осторожность при любых действиях, требующих умственной активности, таких как эксплуатация автотранспортного средства или опасного оборудования. Менее распространенные побочные эффекты включают судороги (1 из 125 пациентов) и гипотиреоз (1 из 250 пациентов).

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Как и в случае других антипсихотических препаратов, долгосрочное применение кветиапина может привести к необратимой поздней дискинезии, неврологическому заболеванию, которое состоит из непроизвольных движений челюсти, губ и языка.

Сообщалось о потенциально смертельном комплексе, называемом нейролептическим злокачественным синдромом (НМС), с антипсихотическими препаратами. Пациенты, у которых развивается НМС, могут иметь высокие лихорадки, жесткость мышц, измененный психический статус, неправильный пульс или артериальное давление, быстрый сердечный ритм, чрезмерное потоотделение и сердечные аритмии.
У животных кветиапин был связан с развитием катаракты, и у пациентов с кветиапином в течение длительных периодов отмечались катаракты. Хотя неясно, ответственен ли кветиапин за катаракту, наблюдаемую у людей, глазные обследования с помощью щелевой лампы (для выявления катаракты до нарушения зрения) рекомендуются в начале лечения и каждые шесть месяцев во время лечения. Если образуются катаракты, лечение следует прекратить.


Кветиапин может увеличить концентрацию холестерина и триглицеридов в крови на 11% и 17% соответственно.

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